| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| cul-2;glp-1 | Double mutant | 1 | 34.95% | ||
| cul-3;daf-2 | Double mutant | 1 | 35.48% | ||
| cul-3;glp-1 | Double mutant | 1 | 12.37% | ||
| cul-4;daf-2 | Double mutant | 1 | 40.86% | ||
| cul-4;glp-1 | Double mutant | 1 | 32.26% | ||
| cul-5;daf-2 | Double mutant | 1 | 48.92% | ||
| cul-5;glp-1 | Double mutant | 1 | 42.47% | ||
| cul-6;daf-2 | Double mutant | 1 | 40.86% | ||
| cul-6;glp-1 | Double mutant | 1 | 39.25% | ||
| cup-4;eat-2 | Double mutant | 2 | 0.52% .. 8.21% | ||
| cup-4;nlp-7 | Double mutant | 2 | -16.74% .. -15.45% | ||
| cup-4;npl-7 | Double mutant | 4 | -24.43% .. -11.76% | ||
| cup-4;skn-1 | Double mutant | 2 | -31.67% .. -20.00% | ||
| cutl-28;daf-16;rrf-3 | Triple mutant | 1 | -25.75% | ||
| cyc-1;daf-16 | Double mutant | 3 | 46.86% .. 53.80% | ||
| cyc-1;daf-16;skn-1 | Triple mutant | 2 | 5.95% .. 9.68% | ||
| cyc-1;daf-2 | Double mutant | 1 | 20.36% .. 388.24% | [est.] | |
| cyc-1;fem-1;fer-15 | Triple mutant | 1 | -30.39% .. 182.35% | [est.] | |
| cyc-1;hif-1 | Double mutant | 1 | 62.50% | ||
| cyc-1;nhr-49 | Double mutant | 1 | -12.43% | ||
| cyc-1;nhr-80 | Double mutant | 2 | 18.18% .. 64.10% | ||
| cyc-1;pha-4 | Double mutant | 1 | 35.19% | ||
| cyc-1;smk-1 | Double mutant | 1 | 46.29% | ||
| cyc-2.1;daf-12 | Double mutant | 1 | -12.99% .. 252.94% | [est.] | |
| cyc-2.1;daf-16 | Double mutant | 1 | -27.49% .. 194.12% | [est.] | |
| cyc-2.1;daf-2 | Double mutant | 2 | 242.50% .. 264.02% | ||
| cyc-2.1;daf-2;rsks-1 | Triple mutant | 2 | 226.50% .. 246.03% | ||
| cyc-2.1;drp-1 | Double mutant | 3 | 45.55% .. 58.82% | ||
| cyc-2.1;rsks-1 | Double mutant | 2 | 44.00% .. 65.08% | ||
| cye-1;daf-12 | Double mutant | 3 | -4.41% .. -1.55% | ||
| cye-1;daf-16 | Double mutant | 7 | -15.34% .. 0.53% | ||
| cye-1;daf-2 | Double mutant | 2 | 197.45% .. 206.32% | ||
| cye-1;daf-9 | Double mutant | 3 | -4.41% .. 3.11% | ||
| cye-1;glp-1 | Double mutant | 4 | 22.22% .. 33.85% | ||
| cye-1;kri-1 | Double mutant | 3 | 3.19% .. 11.94% | ||
| cye-1;mes-1 | Double mutant | 5 | 13.99% .. 25.91% | ||
| cye-1;rrf-1 | Double mutant | 3 | 15.71% .. 24.74% | ||
| cye-1;skn-1 | Double mutant | 3 | -22.89% .. -14.89% | ||
| cyp-35A2;fat-5 | Double mutant | 1 | 38.26% | ||
| cyp-42A1;daf-16;daf-2 | Triple mutant | 1 | -57.82% | ||
| cyp-42A1;daf-2 | Double mutant | 1 | -41.50% | ||
| D1069.3;daf-16;daf-2 | Triple mutant | 1 | -31.29% | ||
| D1069.3;daf-2 | Double mutant | 1 | 93.20% | ||
| D2013.7;daf-16;daf-2 | Triple mutant | 1 | -33.50% | ||
| D2013.7;daf-2 | Double mutant | 1 | 119.21% | ||
| D2013.7;eat-2 | Double mutant | 1 | 59.11% | ||
| D2030.4;daf-16 | Double mutant | 1 | 11.98% | ||
| D2085.3;daf-16;daf-2 | Triple mutant | 1 | -34.48% | ||
| D2085.3;daf-2 | Double mutant | 1 | 142.36% | ||
| D2085.3;eat-2 | Double mutant | 1 | 38.42% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
