| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| ifg-1;ire-1 | Caenorhabditis elegans | Double mutant | 1 | -17.74% | ||
| ifg-1;isp-1 | Caenorhabditis elegans | Double mutant | 1 | 50.74% | ||
| ifg-1;let-363 | Caenorhabditis elegans | Double mutant | 1 | 66.67% | ||
| ifg-1;let-711 | Caenorhabditis elegans | Double mutant | 2 | -13.54% .. 3.45% | ||
| ifg-1;mdt-15 | Caenorhabditis elegans | Double mutant | 2 | -21.18% .. -18.14% | ||
| ifg-1;rsks-1 | Caenorhabditis elegans | Double mutant | 1 | 59.38% | ||
| ifg-1;sca-1 | Caenorhabditis elegans | Double mutant | 2 | -31.78% .. -17.73% | ||
| ifg-1;sir-2.1 | Caenorhabditis elegans | Double mutant | 1 | -15.02% .. 244.71% | [est.] | |
| ifg-1;skn-1 | Caenorhabditis elegans | Double mutant | 1 | 17.53% | ||
| ifg-1;unc-70 | Caenorhabditis elegans | Double mutant | 2 | 7.20% .. 8.37% | ||
| ifta-2;osm-5 | Caenorhabditis elegans | Double mutant | 1 | 27.37% | ||
| iftb-1;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | -27.78% .. -112.71% | [est.] | |
| iftb-1;sir-2.1 | Caenorhabditis elegans | Double mutant | 2 | -41.42% .. -168.0% | [est.] | |
| ins-18;ins-18;ins-7 | Caenorhabditis elegans | Triple mutant | 1 | 22.94% | ||
| ins-18;ins-7 | Caenorhabditis elegans | Double mutant | 1 | 15.04% | ||
| ins-18;rrf-3 | Caenorhabditis elegans | Double mutant | 2 | -54.47% .. -220.94% | [est.] | |
| ins-1;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -46.93% .. 115.29% | [est.] | |
| ins-21;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -52.73% .. 91.76% | [est.] | |
| ins-22;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | -54.18% .. 85.88% | [est.] | |
| ins-7;rrf-3 | Caenorhabditis elegans | Double mutant | 2 | -42.0% .. -170.35% | [est.] | |
| ire-1;isp-1 | Caenorhabditis elegans | Double mutant | 5 | 8.42% .. 41.61% | ||
| ire-1;sod-1 | Caenorhabditis elegans | Double mutant | 2 | -1.38% .. 8.12% | ||
| isp-1;junB | Caenorhabditis elegans | Double mutant | 1 | -57.69% .. 71.65% | [est.] | |
| isp-1;kin-29 | Caenorhabditis elegans | Double mutant | 1 | 57.56% | ||
| isp-1;let-711 | Caenorhabditis elegans | Double mutant | 1 | 25.62% | ||
| isp-1;mdt-15 | Caenorhabditis elegans | Double mutant | 1 | 25.12% | ||
| isp-1;mml-1 | Caenorhabditis elegans | Double mutant | 1 | 78.49% | ||
| isp-1;nhr-105 | Caenorhabditis elegans | Double mutant | 1 | -19.52% .. 226.47% | [est.] | |
| isp-1;nhr-125 | Caenorhabditis elegans | Double mutant | 1 | -17.89% .. 233.06% | [est.] | |
| isp-1;nhr-214 | Caenorhabditis elegans | Double mutant | 1 | -19.58% .. 226.24% | [est.] | |
| isp-1;nhr-27 | Caenorhabditis elegans | Double mutant | 1 | -32.92% .. 172.12% | [est.] | |
| isp-1;nhr-49 | Caenorhabditis elegans | Double mutant | 1 | -48.49% .. 108.94% | [est.] | |
| isp-1;nuo-6 | Caenorhabditis elegans | Double mutant | 3 | 45.19% .. 129.63% | ||
| isp-1;par-4 | Caenorhabditis elegans | Double mutant | 1 | 73.84% | ||
| isp-1;pha-4 | Caenorhabditis elegans | Double mutant | 1 | 14.15% | ||
| isp-1;rps-15 | Caenorhabditis elegans | Double mutant | 2 | -16.47% .. -66.82% | [est.] | |
| isp-1;rps-22 | Caenorhabditis elegans | Double mutant | 1 | -12.7% .. 254.12% | [est.] | |
| isp-1;rsks-1 | Caenorhabditis elegans | Double mutant | 1 | -12.41% .. 255.29% | [est.] | |
| isp-1;sad-1 | Caenorhabditis elegans | Double mutant | 1 | 88.95% | ||
| isp-1;sca-1 | Caenorhabditis elegans | Double mutant | 1 | 44.83% | ||
| isp-1;smk-1 | Caenorhabditis elegans | Double mutant | 1 | 42.62% | ||
| isp-1;sod-2 | Caenorhabditis elegans | Double mutant | 1 | -4.52% | ||
| isp-1;taf-4 | Caenorhabditis elegans | Double mutant | 1 | -44.2% .. 126.35% | [est.] | |
| isp-1;tbx-2 | Caenorhabditis elegans | Double mutant | 1 | -16.65% .. 238.12% | [est.] | |
| isp-1;tcer-1 | Caenorhabditis elegans | Double mutant | 1 | -24.3% .. 207.06% | [est.] | |
| isp-1;ubc-18 | Caenorhabditis elegans | Double mutant | 2 | 42.86% | ||
| isp-1;unc-70 | Caenorhabditis elegans | Double mutant | 1 | 46.31% | ||
| isp-1;vhl-1 | Caenorhabditis elegans | Double mutant | 2 | 63.89% .. 70.59% | ||
| isp-1;wwp-1 | Caenorhabditis elegans | Double mutant | 2 | 52.72% | ||
| isp-1;Y62E10A.17 | Caenorhabditis elegans | Double mutant | 1 | -16.88% .. 237.18% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group