| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| cku-70;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 131.21% | ||
| cku-70;daf-2;glp-4 | Caenorhabditis elegans | Triple mutant | 1 | 162.41% | ||
| cku-70;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | 9.93% | ||
| cku-80;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 59.57% | ||
| cku-80;daf-2;glp-4 | Caenorhabditis elegans | Triple mutant | 1 | 134.75% | ||
| cku-80;rrf-3 | Caenorhabditis elegans | Double mutant | 1 | 4.26% | ||
| clk-10;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 80.76% | ||
| clk-1;clk-2 | Caenorhabditis elegans | Double mutant | 6 | 37.73% .. 89.93% | ||
| clk-1;clk-3 | Caenorhabditis elegans | Double mutant | 6 | 10.56% .. 191.95% | ||
| clk-1;cup-4 | Caenorhabditis elegans | Double mutant | 2 | 26.74% .. 33.54% | ||
| clk-1;daf-16 | Caenorhabditis elegans | Double mutant | 3 | -15.30% .. 36.24% | ||
| clk-1;daf-2 | Caenorhabditis elegans | Double mutant | 5 | 60.43% .. 477.65% | ||
| clk-1;drp-1 | Caenorhabditis elegans | Double mutant | 1 | 76.58% | ||
| clk-1;eat-2 | Caenorhabditis elegans | Double mutant | 2 | 21.00% .. 39.59% | ||
| clk-1;egl-1 | Caenorhabditis elegans | Double mutant | 1 | 32.03% | ||
| clk-1;egl-9 | Caenorhabditis elegans | Double mutant | 1 | 31.94% | ||
| clk-1;hif-1 | Caenorhabditis elegans | Double mutant | 3 | -4.91% .. 54.70% | ||
| clk-1;ife-2 | Caenorhabditis elegans | Double mutant | 1 | 63.19% | ||
| clk-1;ifg-1 | Caenorhabditis elegans | Double mutant | 1 | -30.1% .. 183.53% | [est.] | |
| clk-1;mekk-3 | Caenorhabditis elegans | Double mutant | 2 | 49.66% .. 106.76% | ||
| clk-1;nlp-7 | Caenorhabditis elegans | Double mutant | 2 | 28.49% .. 34.16% | ||
| clk-1;prmt-1 | Caenorhabditis elegans | Double mutant | 1 | -43.16% .. 130.59% | [est.] | |
| clk-1;rsks-1 | Caenorhabditis elegans | Double mutant | 1 | -35.9% .. 160.0% | [est.] | |
| clk-1;skn-1 | Caenorhabditis elegans | Double mutant | 2 | 12.79% .. 18.63% | ||
| clk-1;smk-1 | Caenorhabditis elegans | Double mutant | 1 | -9.29% | ||
| clk-1;sod-2 | Caenorhabditis elegans | Double mutant | 1 | 146.89% | ||
| clk-1;unc-51 | Caenorhabditis elegans | Double mutant | 1 | -23.14% .. 211.76% | [est.] | |
| clk-1;vhl-1 | Caenorhabditis elegans | Double mutant | 2 | 33.33% .. 41.10% | ||
| clk-2;clk-3 | Caenorhabditis elegans | Double mutant | 3 | 27.95% .. 49.66% | ||
| clk-2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 268.35% | ||
| clk-2;gro-1 | Caenorhabditis elegans | Double mutant | 2 | -17.45% | ||
| clk-3;daf-16 | Caenorhabditis elegans | Double mutant | 1 | 28.86% | ||
| clk-3;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 123.09% | ||
| clk-3;gro-1 | Caenorhabditis elegans | Double mutant | 3 | -9.32% .. 6.71% | ||
| clk-4;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 123.09% | ||
| clk-5;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 85.18% | ||
| clk-7;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 139.97% | ||
| clk-8;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 130.73% | ||
| clk-9;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 136.75% | ||
| cmk-1;trpa-1 | Caenorhabditis elegans | Double mutant | 2 | 48.86% .. 58.18% | ||
| cnc-2;rrf-3 | Caenorhabditis elegans | Double mutant | 2 | -24.01% .. -97.41% | [est.] | |
| cnc-7;rrf-3 | Caenorhabditis elegans | Double mutant | 2 | -28.07% .. -113.88% | [est.] | |
| col-127;daf-2 | Caenorhabditis elegans | Double mutant | 1 | -24.88% .. 204.71% | [est.] | |
| col-13;daf-2 | Caenorhabditis elegans | Double mutant | 1 | -31.26% .. 178.82% | [est.] | |
| col-144;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 60.00% .. 130.71% | ||
| col-84;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -40.82% | ||
| col-84;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 65.99% | ||
| Cp;Heph | Mus musculus | Double mutant | 1 | -83.52% .. -52.96% | [est.] | |
| cst-1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -14.72% | ||
| cst-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 7.25% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group