| All mutants (1790 results, without single mutants) | Organism | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|---|
| ctb-1;drp-1;isp-1 | Caenorhabditis elegans | Triple mutant | 1 | 78.98% | ||
| ctb-1;isp-1 | Caenorhabditis elegans | Double mutant | 8 | 27.21% .. 67.35% | ||
| ctl-1;ctl-2;ctl-3 | Caenorhabditis elegans | Triple mutant | 3 | -55.92% .. -226.82% | [est.] | |
| ctl-1;ctl-2;ctl-3;sod-1 | Caenorhabditis elegans | 4-mutant | 2 | -42.0% .. -170.35% | [est.] | |
| ctl-1;ctl-2;ctl-3;sod-2 | Caenorhabditis elegans | 4-mutant | 2 | -39.68% .. -160.94% | [est.] | |
| ctl-1;ctl-2;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 5-mutant | 1 | -28.36% .. 190.59% | [est.] | |
| ctl-1;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 2 | -31.26% .. -126.82% | [est.] | |
| ctl-1;daf-2;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -6.03% .. 281.18% | [est.] | |
| ctl-2;daf-2;fem-1;fer-15 | Caenorhabditis elegans | 4-mutant | 3 | -60.56% .. -245.65% | [est.] | |
| ctl-2;daf-2;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -2.84% .. 294.12% | [est.] | |
| ctl-2;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -60.85% .. 58.82% | [est.] | |
| cua-1;daf-16;daf-2 | Caenorhabditis elegans | Triple mutant | 1 | -35.37% | ||
| cua-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | -25.17% | ||
| cul-1;daf-2 | Caenorhabditis elegans | Double mutant | 10 | 15.59% | ||
| cul-1;eat-2 | Caenorhabditis elegans | Double mutant | 2 | -26.91% .. -109.18% | [est.] | |
| cul-1;glp-1 | Caenorhabditis elegans | Double mutant | 3 | 21.51% .. 22.58% | ||
| cul-2;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 48.39% | ||
| cul-2;glp-1 | Caenorhabditis elegans | Double mutant | 1 | 34.95% | ||
| cul-3;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 35.48% | ||
| cul-3;glp-1 | Caenorhabditis elegans | Double mutant | 1 | 12.37% | ||
| cul-4;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 40.86% | ||
| cul-4;glp-1 | Caenorhabditis elegans | Double mutant | 1 | 32.26% | ||
| cul-5;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 48.92% | ||
| cul-5;glp-1 | Caenorhabditis elegans | Double mutant | 1 | 42.47% | ||
| cul-6;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 40.86% | ||
| cul-6;glp-1 | Caenorhabditis elegans | Double mutant | 1 | 39.25% | ||
| cup-4;eat-2 | Caenorhabditis elegans | Double mutant | 2 | 0.52% .. 8.21% | ||
| cup-4;nlp-7 | Caenorhabditis elegans | Double mutant | 2 | -16.74% .. -15.45% | ||
| cup-4;npl-7 | Caenorhabditis elegans | Double mutant | 4 | -24.43% .. -11.76% | ||
| cup-4;skn-1 | Caenorhabditis elegans | Double mutant | 2 | -31.67% .. -20.00% | ||
| cutl-28;daf-16;rrf-3 | Caenorhabditis elegans | Triple mutant | 1 | -25.75% | ||
| cyc-1;daf-16 | Caenorhabditis elegans | Double mutant | 3 | 46.86% .. 53.80% | ||
| cyc-1;daf-16;skn-1 | Caenorhabditis elegans | Triple mutant | 2 | 5.95% .. 9.68% | ||
| cyc-1;daf-2 | Caenorhabditis elegans | Double mutant | 1 | 20.36% .. 388.24% | [est.] | |
| cyc-1;fem-1;fer-15 | Caenorhabditis elegans | Triple mutant | 1 | -30.39% .. 182.35% | [est.] | |
| cyc-1;hif-1 | Caenorhabditis elegans | Double mutant | 1 | 62.50% | ||
| cyc-1;nhr-49 | Caenorhabditis elegans | Double mutant | 1 | -12.43% | ||
| cyc-1;nhr-80 | Caenorhabditis elegans | Double mutant | 2 | 18.18% .. 64.10% | ||
| cyc-1;pha-4 | Caenorhabditis elegans | Double mutant | 1 | 35.19% | ||
| cyc-1;smk-1 | Caenorhabditis elegans | Double mutant | 1 | 46.29% | ||
| cyc-2.1;daf-12 | Caenorhabditis elegans | Double mutant | 1 | -12.99% .. 252.94% | [est.] | |
| cyc-2.1;daf-16 | Caenorhabditis elegans | Double mutant | 1 | -27.49% .. 194.12% | [est.] | |
| cyc-2.1;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 242.50% .. 264.02% | ||
| cyc-2.1;daf-2;rsks-1 | Caenorhabditis elegans | Triple mutant | 2 | 226.50% .. 246.03% | ||
| cyc-2.1;drp-1 | Caenorhabditis elegans | Double mutant | 3 | 45.55% .. 58.82% | ||
| cyc-2.1;rsks-1 | Caenorhabditis elegans | Double mutant | 2 | 44.00% .. 65.08% | ||
| cye-1;daf-12 | Caenorhabditis elegans | Double mutant | 3 | -4.41% .. -1.55% | ||
| cye-1;daf-16 | Caenorhabditis elegans | Double mutant | 7 | -15.34% .. 0.53% | ||
| cye-1;daf-2 | Caenorhabditis elegans | Double mutant | 2 | 197.45% .. 206.32% | ||
| cye-1;daf-9 | Caenorhabditis elegans | Double mutant | 3 | -4.41% .. 3.11% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group