| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| hsf-1;old-1 | Double mutant | 1 | -27.59% | ||
| hsf-1;pkc-2 | Double mutant | 1 | -44.14% | ||
| hsf-1;ragc-1 | Double mutant | 2 | -35.83% .. -30.65% | ||
| hsf-1;rps-15 | Double mutant | 2 | -45.65% .. -19.77% | ||
| hsf-1;rps-6 | Double mutant | 2 | -34.24% .. -19.77% | ||
| hsf-1;rrf3 | Double mutant | 1 | -27.80% | ||
| hsf-1;rsks-1 | Double mutant | 9 | -65.09% .. -25.26% | ||
| hsf-1;sod-1 | Double mutant | 2 | -51.28% .. -208.0% | [est.] | |
| hsf-1;trpa-1 | Double mutant | 1 | -3.53% | ||
| hsp-16.1;hsp-16.11;hsp-16.2 | Triple mutant | 2 | -10.49% .. -5.06% | ||
| hsp-16.1;hsp-16.11;hsp-16.2;rsks-1 | 4-mutant | 2 | -7.41% .. 19.66% | ||
| hsp-70;rsks-1 | Double mutant | 2 | 7.41% .. 18.54% | ||
| ife-2;let-363 | Double mutant | 2 | 65.52% | ||
| ife-2;mnk-1 | Double mutant | 1 | 38.46% | ||
| ife-2;rps-15 | Double mutant | 2 | -35.03% .. -142.12% | [est.] | |
| ife-2;rskn-1 | Double mutant | 1 | 47.80% | ||
| ife-2;rsks-1 | Double mutant | 2 | 51.65% | ||
| ife-2;skn-1 | Double mutant | 1 | 9.81% | ||
| ifg-1;ifg-1 | Double mutant | 1 | 43.84% | ||
| ifg-1;ire-1 | Double mutant | 1 | -17.74% | ||
| ifg-1;isp-1 | Double mutant | 1 | 50.74% | ||
| ifg-1;let-363 | Double mutant | 1 | 66.67% | ||
| ifg-1;let-711 | Double mutant | 2 | -13.54% .. 3.45% | ||
| ifg-1;mdt-15 | Double mutant | 2 | -21.18% .. -18.14% | ||
| ifg-1;rsks-1 | Double mutant | 1 | 59.38% | ||
| ifg-1;sca-1 | Double mutant | 2 | -31.78% .. -17.73% | ||
| ifg-1;sir-2.1 | Double mutant | 1 | -15.02% .. 244.71% | [est.] | |
| ifg-1;skn-1 | Double mutant | 1 | 17.53% | ||
| ifg-1;unc-70 | Double mutant | 2 | 7.20% .. 8.37% | ||
| ifta-2;osm-5 | Double mutant | 1 | 27.37% | ||
| iftb-1;rsks-1 | Double mutant | 2 | -27.78% .. -112.71% | [est.] | |
| iftb-1;sir-2.1 | Double mutant | 2 | -41.42% .. -168.0% | [est.] | |
| ins-18;ins-18;ins-7 | Triple mutant | 1 | 22.94% | ||
| ins-18;ins-7 | Double mutant | 1 | 15.04% | ||
| ins-18;rrf-3 | Double mutant | 2 | -54.47% .. -220.94% | [est.] | |
| ins-1;rrf-3 | Double mutant | 1 | -46.93% .. 115.29% | [est.] | |
| ins-21;rrf-3 | Double mutant | 1 | -52.73% .. 91.76% | [est.] | |
| ins-22;rrf-3 | Double mutant | 1 | -54.18% .. 85.88% | [est.] | |
| ins-7;rrf-3 | Double mutant | 2 | -42.0% .. -170.35% | [est.] | |
| ire-1;isp-1 | Double mutant | 5 | 8.42% .. 41.61% | ||
| ire-1;sod-1 | Double mutant | 2 | -1.38% .. 8.12% | ||
| isp-1;junB | Double mutant | 1 | -57.69% .. 71.65% | [est.] | |
| isp-1;kin-29 | Double mutant | 1 | 57.56% | ||
| isp-1;let-711 | Double mutant | 1 | 25.62% | ||
| isp-1;mdt-15 | Double mutant | 1 | 25.12% | ||
| isp-1;mml-1 | Double mutant | 1 | 78.49% | ||
| isp-1;nhr-105 | Double mutant | 1 | -19.52% .. 226.47% | [est.] | |
| isp-1;nhr-125 | Double mutant | 1 | -17.89% .. 233.06% | [est.] | |
| isp-1;nhr-214 | Double mutant | 1 | -19.58% .. 226.24% | [est.] | |
| isp-1;nhr-27 | Double mutant | 1 | -32.92% .. 172.12% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
