| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| isp-1;nhr-49 | Double mutant | 1 | -48.49% .. 108.94% | [est.] | |
| isp-1;nuo-6 | Double mutant | 3 | 45.19% .. 129.63% | ||
| isp-1;par-4 | Double mutant | 1 | 73.84% | ||
| isp-1;pha-4 | Double mutant | 1 | 14.15% | ||
| isp-1;rps-15 | Double mutant | 2 | -16.47% .. -66.82% | [est.] | |
| isp-1;rps-22 | Double mutant | 1 | -12.7% .. 254.12% | [est.] | |
| isp-1;rsks-1 | Double mutant | 1 | -12.41% .. 255.29% | [est.] | |
| isp-1;sad-1 | Double mutant | 1 | 88.95% | ||
| isp-1;sca-1 | Double mutant | 1 | 44.83% | ||
| isp-1;smk-1 | Double mutant | 1 | 42.62% | ||
| isp-1;sod-2 | Double mutant | 1 | -4.52% | ||
| isp-1;taf-4 | Double mutant | 1 | -44.2% .. 126.35% | [est.] | |
| isp-1;tbx-2 | Double mutant | 1 | -16.65% .. 238.12% | [est.] | |
| isp-1;tcer-1 | Double mutant | 1 | -24.3% .. 207.06% | [est.] | |
| isp-1;ubc-18 | Double mutant | 2 | 42.86% | ||
| isp-1;unc-70 | Double mutant | 1 | 46.31% | ||
| isp-1;vhl-1 | Double mutant | 2 | 63.89% .. 70.59% | ||
| isp-1;wwp-1 | Double mutant | 2 | 52.72% | ||
| isp-1;Y62E10A.17 | Double mutant | 1 | -16.88% .. 237.18% | [est.] | |
| jkk-1;shc-1 | Double mutant | 2 | -32.50% .. -18.11% | ||
| jnk-1;shc-1 | Double mutant | 2 | -23.24% | ||
| jnk-1;trpa-1 | Double mutant | 1 | -2.33% | ||
| jun-1;tpk-1 | Double mutant | 1 | -39.24% .. 146.47% | [est.] | |
| K04G7.4;rrf-3;sir-2.1 | Triple mutant | 1 | -39.82% .. 144.12% | [est.] | |
| K08D10.7;rrf-3;sir-2.1 | Triple mutant | 1 | -56.38% .. 76.94% | [est.] | |
| K08E3.5;rrf-3;sir-2.1 | Triple mutant | 1 | -54.32% .. 85.29% | [est.] | |
| K11D12.1;rrf-3;sir-2.1 | Triple mutant | 1 | -59.4% .. 64.71% | [est.] | |
| kin-29;nuo-2 | Double mutant | 1 | -8.72% | ||
| kri-1;raga-1 | Double mutant | 3 | 28.67% .. 32.11% | ||
| kri-1;tcer-1 | Double mutant | 4 | -24.64% .. 3.64% | ||
| lbp-7;rrf-3 | Double mutant | 2 | -52.73% .. -213.88% | [est.] | |
| let-363;nhr-62 | Double mutant | 2 | 30.53% .. 39.14% | ||
| let-363;pep-2 | Double mutant | 2 | 43.64% .. 63.24% | ||
| let-363;rsks-1 | Double mutant | 3 | -16.15% | ||
| let-363;sir-2.1 | Double mutant | 3 | -48.96% .. -198.59% | [est.] | |
| let-711;rsks-1 | Double mutant | 1 | 38.42% | ||
| lgg-1;LPL-4 | Double mutant | 3 | -12.22% .. | ||
| lin-14;lin-4 | Double mutant | 2 | -5.26% .. 13.70% | ||
| lin-15b;nhr-21;nre-1 | Triple mutant | 1 | -60.76% .. 59.18% | [est.] | |
| lin-15b;nhr-35;nre-1 | Triple mutant | 2 | -67.08% .. -272.12% | [est.] | |
| lin-15b;nhr-49;nre-1 | Triple mutant | 1 | -68.16% .. 29.18% | [est.] | |
| lin-15b;nhr-4;nre-1 | Triple mutant | 1 | -57.37% .. 72.94% | [est.] | |
| lin-15b;nhr-62;nre-1 | Triple mutant | 4 | -61.86% .. -250.94% | [est.] | |
| lin-15b;nre-1 | Double mutant | 5 | -66.53% .. -269.88% | [est.] | |
| lin-15b;nre-1;pha-4 | Triple mutant | 1 | -60.41% .. 60.59% | [est.] | |
| LPL-4;pha-4 | Double mutant | 3 | -11.35% .. -0.53% | ||
| LPL-4;tor | Double mutant | 3 | 16.22% .. 31.05% | ||
| LPL-4;vps-34 | Double mutant | 3 | -9.24% .. 7.81% | ||
| mdl-1;mxl-2 | Double mutant | 1 | -7.53% | ||
| mdt-15;rsks-1 | Double mutant | 1 | -4.93% |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
