Roundworm

Roundworm

Caenorhabditis elegans, the most popular nematode.

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All mutants (1727 results, without single mutants) Mutant type No. experiments Change in average lifespan   Epistasis
isp-1;nhr-49 Double mutant 1 -48.49% .. 108.94% [est.]
isp-1;nuo-6 Double mutant 3 45.19% .. 129.63%  
isp-1;par-4 Double mutant 1 73.84%  
isp-1;pha-4 Double mutant 1 14.15%  
isp-1;rps-15 Double mutant 2 -16.47% .. -66.82% [est.]
isp-1;rps-22 Double mutant 1 -12.7% .. 254.12% [est.]
isp-1;rsks-1 Double mutant 1 -12.41% .. 255.29% [est.]
isp-1;sad-1 Double mutant 1 88.95%  
isp-1;sca-1 Double mutant 1 44.83%  
isp-1;smk-1 Double mutant 1 42.62%  
isp-1;sod-2 Double mutant 1 -4.52%  
isp-1;taf-4 Double mutant 1 -44.2% .. 126.35% [est.]
isp-1;tbx-2 Double mutant 1 -16.65% .. 238.12% [est.]
isp-1;tcer-1 Double mutant 1 -24.3% .. 207.06% [est.]
isp-1;ubc-18 Double mutant 2 42.86%  
isp-1;unc-70 Double mutant 1 46.31%  
isp-1;vhl-1 Double mutant 2 63.89% .. 70.59%  
isp-1;wwp-1 Double mutant 2 52.72%  
isp-1;Y62E10A.17 Double mutant 1 -16.88% .. 237.18% [est.]
jkk-1;shc-1 Double mutant 2 -32.50% .. -18.11%  
jnk-1;shc-1 Double mutant 2 -23.24%  
jnk-1;trpa-1 Double mutant 1 -2.33%  
jun-1;tpk-1 Double mutant 1 -39.24% .. 146.47% [est.]
K04G7.4;rrf-3;sir-2.1 Triple mutant 1 -39.82% .. 144.12% [est.]
K08D10.7;rrf-3;sir-2.1 Triple mutant 1 -56.38% .. 76.94% [est.]
K08E3.5;rrf-3;sir-2.1 Triple mutant 1 -54.32% .. 85.29% [est.]
K11D12.1;rrf-3;sir-2.1 Triple mutant 1 -59.4% .. 64.71% [est.]
kin-29;nuo-2 Double mutant 1 -8.72%  
kri-1;raga-1 Double mutant 3 28.67% .. 32.11%  
kri-1;tcer-1 Double mutant 4 -24.64% .. 3.64%  
lbp-7;rrf-3 Double mutant 2 -52.73% .. -213.88% [est.]
let-363;nhr-62 Double mutant 2 30.53% .. 39.14%  
let-363;pep-2 Double mutant 2 43.64% .. 63.24%  
let-363;rsks-1 Double mutant 3 -16.15%  
let-363;sir-2.1 Double mutant 3 -48.96% .. -198.59% [est.]
let-711;rsks-1 Double mutant 1 38.42%  
lgg-1;LPL-4 Double mutant 3 -12.22% ..  
lin-14;lin-4 Double mutant 2 -5.26% .. 13.70%  
lin-15b;nhr-21;nre-1 Triple mutant 1 -60.76% .. 59.18% [est.]
lin-15b;nhr-35;nre-1 Triple mutant 2 -67.08% .. -272.12% [est.]
lin-15b;nhr-49;nre-1 Triple mutant 1 -68.16% .. 29.18% [est.]
lin-15b;nhr-4;nre-1 Triple mutant 1 -57.37% .. 72.94% [est.]
lin-15b;nhr-62;nre-1 Triple mutant 4 -61.86% .. -250.94% [est.]
lin-15b;nre-1 Double mutant 5 -66.53% .. -269.88% [est.]
lin-15b;nre-1;pha-4 Triple mutant 1 -60.41% .. 60.59% [est.]
LPL-4;pha-4 Double mutant 3 -11.35% .. -0.53%  
LPL-4;tor Double mutant 3 16.22% .. 31.05%  
LPL-4;vps-34 Double mutant 3 -9.24% .. 7.81%  
mdl-1;mxl-2 Double mutant 1 -7.53%  
mdt-15;rsks-1 Double mutant 1 -4.93%  
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group