| All mutants (1727 results, without single mutants) | Mutant type | No. experiments | Change in average lifespan | Epistasis | |
|---|---|---|---|---|---|
| mek-1;shc-1 | Double mutant | 2 | -31.50% .. 2.76% | ||
| mekk-3;mev-1 | Double mutant | 2 | -20.82% .. 25.68% | ||
| mekk-3;nhr-49 | Double mutant | 4 | -34.62% .. 43.62% | ||
| mekk-3;nhr-8 | Double mutant | 2 | -27.29% .. -1.09% | ||
| mekk-3;pgp-3 | Double mutant | 4 | 6.58% .. 15.55% | ||
| mekk-3;pha-4;smg-1 | Triple mutant | 2 | -19.26% .. -78.12% | [est.] | |
| mekk-3;rde-1 | Double mutant | 2 | -3.50% .. 6.94% | ||
| mekk-3;skn-1 | Double mutant | 2 | 42.94% .. 59.36% | ||
| mekk-3;smg-1 | Double mutant | 2 | -2.26% .. -9.18% | [est.] | |
| mes-1;pha-4 | Double mutant | 1 | -28.28% | ||
| mes-1;vps-34 | Double mutant | 1 | 3.64% | ||
| mev-1;unc-51 | Double mutant | 1 | -52.44% .. 92.94% | [est.] | |
| mml-1;nuo-2 | Double mutant | 1 | 55.81% | ||
| mpk-1;skn-1 | Double mutant | 2 | -65.08% .. -264.0% | [est.] | |
| mtl-2;rrf-3 | Double mutant | 2 | -55.05% .. -223.29% | [est.] | |
| mxl-1;mxl-2 | Double mutant | 1 | -7.53% | ||
| mxl-1;pha | Double mutant | 1 | -29.97% | ||
| mxl-2;pha | Double mutant | 1 | -34.01% | ||
| nhr-105;tpk-1 | Double mutant | 1 | -18.97% .. 228.71% | [est.] | |
| nhr-147;rrf-3 | Double mutant | 1 | -28.94% .. 188.24% | [est.] | |
| nhr-170;nhr-231;rrf-3 | Triple mutant | 1 | -23.14% .. 211.76% | [est.] | |
| nhr-27;tpk-1 | Double mutant | 1 | -3.8% .. 290.24% | [est.] | |
| nhr-49;tcer-1 | Double mutant | 1 | -30.54% | ||
| nmur-1;osm-3 | Double mutant | 4 | 13.77% .. 44.76% | ||
| nmur-1;pmk-1 | Double mutant | 1 | 14.52% | ||
| npl-7;skn-1 | Double mutant | 4 | -22.62% .. -19.46% | ||
| nspe-7;rrf-3 | Double mutant | 1 | -27.78% .. 192.94% | [est.] | |
| nuc-1;rrf-3 | Double mutant | 2 | -52.44% .. -212.71% | [est.] | |
| nuo-2;par-4 | Double mutant | 1 | 36.63% | ||
| nuo-2;sad-1 | Double mutant | 1 | 6.98% | ||
| nuo-6;sod-1 | Double mutant | 1 | 1.51% .. 311.76% | [est.] | |
| nuo-6;sod-2 | Double mutant | 1 | 5.86% .. 329.41% | [est.] | |
| ocr-2;osm-9 | Double mutant | 2 | 28.70% .. 48.83% | ||
| ocr-2;osm-9;tax-6 | Triple mutant | 1 | 34.23% | ||
| oga-1;ogt-1 | Double mutant | 1 | -2.52% | ||
| oga-1;pdk-1 | Double mutant | 1 | 17.61% | ||
| oga-1;sgk-1 | Double mutant | 1 | 64.78% | ||
| ogt-1;sgk-1 | Double mutant | 1 | 4.40% | ||
| old-1;rrf-3 | Double mutant | 2 | -51.57% .. -209.18% | [est.] | |
| par-5;sir-2.1 | Double mutant | 3 | -25.00% .. -5.00% | ||
| pep-2;rrf-3 | Double mutant | 1 | -50.41% .. 101.18% | [est.] | |
| pes-2;rrf-3 | Double mutant | 2 | -51.28% .. -208.0% | [est.] | |
| pha-4;pkc-2 | Double mutant | 1 | -19.33% | ||
| pha-4;smg-1 | Double mutant | 3 | -24.88% .. -100.94% | [est.] | |
| pha-4;trpa-1 | Double mutant | 1 | -14.51% | ||
| pha-4;wwp-1 | Double mutant | 3 | -12.30% .. -6.42% | ||
| pkc-2;sgk-1 | Double mutant | 3 | -19.90% .. 22.97% | ||
| pkc-2;skn-1 | Double mutant | 1 | -11.11% | ||
| pkc-2;trpa-1 | Double mutant | 7 | -20.00% .. 35.74% | ||
| pme-1;rrf-3 | Double mutant | 1 | -65.2% .. 41.18% | [est.] |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
